Epigenetic profile of endometrial proliferation in the different morphotypes of endometrial hyperplasia
نویسندگان
چکیده
Research aim: to investigate the proliferative status of endometrium in different morphotypes endometrial hyperplasia based upon identification key molecular markers cell cycle.Materials and methods. Endometrial samples taken from 137 women were investigated: 40 – normal (NE), 61 non-atypical (ЕH), 36 atypical (AHE). Expression gene cyclin D1, nuclear antigen Кі-67, glycoproteins Е-cadherin β-catenin, estradiol receptors (ER) progesterone (PGR) investigated. Results. ER expression NE was high phase decreased significantly secretory phase. PGR both phases. EH glandular (180 ± 8.3) stromal cells (170.5 4.1) exceed indicators (197.5 9.3) NE. reliably if there AHE. 2.6 times lower (74.6 3.9) compere (p <0.05) 2.4 (р <0.05). AHE dropped 30.3 2.8, which 5.5–5.6 than <0.002). 2.5–2.7 (71.1 2.3) glands 2.8 Gene D1 increased EH. Protein Кі-67 2.9 We discovered strong direction decreasing it lowest for Opposite β-catenin. The highest numbers positive observed 100%. negative β-catenin (32,5–35%).Conclusion. epigenetic profile investigation will be useful future development carcinogenesis risk stratification, identifying patients with cancer also choosing optimal way influence pathological process endometrium.
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ژورنال
عنوان ژورنال: Reproductive Endocrinology
سال: 2021
ISSN: ['2411-1295', '2309-4117']
DOI: https://doi.org/10.18370/2309-4117.2021.57.68-78